17a-Methyltestosterone

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2.High Quality. Our company is a professional production of hormone intermediates for 10 years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, you can trust us.
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17a-Methyltestosterone Quick Details

State: Solid
Purity: >99%
CAS No.: 58-18-4
storage temp. 2-8°C
Molecular Mass: 302.451
Melting Point:162-168 °C
Sample: Samples Available
Reship Policy: Reship Free
Molecular Formula: C20H30O2
Suitable for: Elderly, Children, Adult, Anti Estrogen
Appearance: white to slightly yellowish-white crystalline

Simple Descriptions About 17a-Methyltestosterone

17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture. The male hormone (17 alpha- methyl testosterone)  is dissolved in alcohol at the dose of 60 milligram per 500 ml of alcohol and then after the alcohol containing hormone is to be mixed with one kg of fry feed. Treated feed is dried in shade and could be stored in freezer until used. This one kg of treated feed will be sufficient to sex reverse 5000 fry of Nile tilapia, Oreochromis niloticus for a 3-week treatment.
17alpha-methyl testosterone is a synthetic androgen with affinity for the androgen receptor. 17alpha-methyl testosterone is used widely as a component of hormone replacement therapy. Previous reports have indicated that contrary to testosterone, 17alpha-methyl testosterone is not aromatized. However, 17alpha-methyl testosterone still could affect local estrogen formation by regulating aromatase expression or by inhibiting aromatase action. Both possibilities have important clinical implications. To evaluate the effect of 17alpha-methyl testosterone on the expression and activity of aromatase, we tested the choriocarcinoma Jar cell line, a cell line that express high levels of P450 aromatase, and the macrophage-like THP-1 cells, which express aromatase only after undergoing differentiation. We found that in both cell lines, 17alpha-methyl testosterone inhibits aromatase activity in a dose-related manner. The curve of inhibition parallels that of Letrozole and gives complete inhibition at 10(-4) M 17alpha-methyl testosterone, determined by the tritium release assay.

17a-Methyltestosterone Specifications